NUCLEAR PHARMACY Validation of a Column Method for Technetium-99m Exametazime Quality Control

نویسندگان

  • George Pandos
  • Stan Penglis
  • Chris Tsopelas
چکیده

Objective: The purpose of this study was to investigate if an octadecyl (18C) minicolumn could be applied successfully for quality control of 99mTc exametazime (HMPAO). Methods: The 18C column system using saline eluent was validated against the Whatman 17 method in calculating the percent radiochemical purity of 99mTc-HMPAO. The behavior of 99mTc-pertechnetate (TcO4) and hydrolyzed-reduced 99mTc (TcO2) on the column was examined, as well as method reproducibility. Results: The column method is reproducible and yields results that are highly comparable to the Whatman 17 method. Technetium-99m-pertechnetate is associated with the eluent, and some TcO2 is retained by the column but this level is insignificant to the final patient dose. Conclusion: The minicolumn system is safe, simple, rapid and reliable for the quality control analysis of routine 99mTcHMPAO preparations.

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تاریخ انتشار 2001